![]() We show that LBD is characterised by altered sphingolipid metabolism with prominent elevation of ceramide species, regardless of GBA mutations. ![]() We investigated relationships between LBD-specific glucocerebrosidase deficits, GBA-related pathways, and α-synuclein levels in brain tissue from LBD and controls, with and without GBA mutations. Despite this genetic association, it remains unclear how GBA mutations increase susceptibility to develop LBD. ![]() Mutations in glucocerebrosidase ( GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD)-collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies.
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